Tumor Targeting by Peptide-Decorated Gold Nanoparticles

Gold Nanoparticles Decorated With Octreotide For Somatostatin Receptors Targeting

Targeted drug delivery systems increase the accumulation of medication in the targeted tissues. In contrast, they reduce the relative concentration of medication in non-targeted tissues and inhibit the non-specific distribution to both liver and spleen. The aim of this study is to formulate nanoparticles that are selectively capable of reaching specific sites in the human body via receptors for...

Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

Cell penetrating peptides (CPPs) are commonly utilized for intracellular delivery of functional materials to circumvent biomembrane barrier. However, further application of CPPs is hindered by lacking selectivity toward targeted cells. The spider venom peptide, lycosin-I, is a CPP with potent cytotoxicity to cancer cells, which might enable lycosin-I to deliver functional materials into cancer ...

Somatostatin Decorated Quantum Dots Nanoparticles for Targeting of Somatostatin Receptors

Due to the unique optical properties like high brightness and narrow emission bands of Quantum dots, it is used as simple fluorescence materials in bio-imaging, immunoassays, microarrays, and other applications. To easy invistigate cell lines that overexpressed somtostatin receptors, somatostatin (SST) was conjugated with Quantum dots carrying PEG amine (Qdots-PEG-NH2). The conjugation of SST t...

Somatostatin Decorated Quantum Dots Nanoparticles for Targeting of Somatostatin Receptors

Due to the unique optical properties like high brightness and narrow emission bands of Quantum dots, it is used as simple fluorescence materials in bio-imaging, immunoassays, microarrays, and other applications. To easy invistigate cell lines that overexpressed somtostatin receptors, somatostatin (SST) was conjugated with Quantum dots carrying PEG amine (Qdots-PEG-NH2). The conjugation of SST t...

Peptide ligation catalyzed by functionalized gold nanoparticles.